Glycogen synthase kinase-3: cryoprotection and glycogen metabolism in the freeze-tolerant wood frog
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Glycogen synthase kinase-3: cryoprotection and glycogen metabolism in the freeze-tolerant wood frog.
The terrestrial anuran Rana sylvatica tolerates extended periods of whole-body freezing during the winter. Freezing survival is facilitated by extensive glycogen hydrolysis and distribution of high concentrations of the cryoprotectant glucose into blood and all tissues. As glycogenesis is both an energy-expensive process and counter-productive to maintaining sustained high cryoprotectant levels...
متن کاملGlycogen Synthase Kinase-3
1Department of Pathology and Centre for Neuroscience, The University of Melbourne and Mental Health Research Institute, Parkville, VIC 3010, Australia 2Neurosignalling Group, Garvan Institute for Medical Research, 384 Victoria St. Darlinghurst, Sydney, NSW 2010, Australia 3Membrane Biology Group, Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK 4 ...
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ژورنال
عنوان ژورنال: Journal of Experimental Biology
سال: 2012
ISSN: 1477-9145,0022-0949
DOI: 10.1242/jeb.065961